Ionotropic Receptors (IRs): Chemosensory ionotropic glutamate receptors in Drosophila and beyond
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چکیده
منابع مشابه
Ionotropic receptors (IRs): chemosensory ionotropic glutamate receptors in Drosophila and beyond.
Ionotropic Receptors (IRs) are a recently characterized family of olfactory receptors in the fruit fly, Drosophila melanogaster. IRs are not related to insect Odorant Receptors (ORs), but rather have evolved from ionotropic glutamate receptors (iGluRs), a conserved family of synaptic ligand-gated ion channels. Here, we review the expression and function of IRs in Drosophila, highlighting simila...
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Ionotropic glutamate receptors (iGluRs) mediate neuronal communication at synapses throughout vertebrate and invertebrate nervous systems. We have characterized a family of iGluR-related genes in Drosophila, which we name ionotropic receptors (IRs). These receptors do not belong to the well-described kainate, AMPA, or NMDA classes of iGluRs, and they have divergent ligand-binding domains that l...
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Most rapid excitatory synaptic signaling is mediated by glutamatergic neurotransmission. An important challenge in neurobiology is to understand the molecular architecture of functional glutamatergic synapses. By combining the techniques of genetics, molecular biology and electrophysiology in C. elegans we have the potential to identify and characterize the molecules that contribute to the func...
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ژورنال
عنوان ژورنال: Insect Biochemistry and Molecular Biology
سال: 2013
ISSN: 0965-1748
DOI: 10.1016/j.ibmb.2013.02.007